Cajun Pork Tenderloin

This savory, juicy Cajun Pork Tenderloin is the perfect main attraction for any dinner. The cajun seasoning provides a ton of flavor without being too spicy, while a two-step roasting process guarantees a tender juicy bite every time.

We love pork tenderloin for how easy it is to cook and how it can take on a variety of flavors from Lemon Garlic to Herb seasoned.

Sliced pork tenderloins in a cast iron skillet


I have cooking Pork Tenderloin using this method for about 15 years now. That’s not to say that I don’t love to throw it on the grill from time to time, but this searing and roasting method has my heart. It’s tender and juicy every single time and it’s perfect for feeding our family of five.

Tenderloin does best with a high heat cooking in a short amount of time. This meal only takes about 30 minutes from prep to finish!

This recipe calls for 2-2 ½ pounds of pork tenderloin. Since each tenderloin will average around a pound, you will use two of them, but try to get two that are about the same size and weight. They are often sold in packs of two, but you’ll want to check with your local store.

An overhead shot of two whole pork tenderloins


There are two steps in the cooking process for pork tenderloin.

  1. Start by preheating your oven to 425 degrees. You want a nice hot oven because it provides even cooking the whole time.
  2. Seasoning the tenderloin with a couple tablespoons of cajun seasoning. You can use my homemade cajun mix or store-bought. I rub in a small amount of brown sugar to balance the spicy with a little sweet.
  3. Heat some olive oil or melt butter in a large, oven proof skillet. I love cast iron, because it will give you the golden sear that you’re looking for. Sear the pork on all sides over medium-high heat for several minutes or until it’s golden brown.
  4. Slide the skillet into the oven and roast for 18 minutes. Yes this number is exact because it’s always been perfect for me. However since ovens can vary in temperature be sure to check the pork with a meat thermometer. It should register between 145 for medium rare and 165 for well done.
  5. Remove the skillet from the oven and tent with foil. Let the meat rest for about 5-10 minutes for the juices to have time to redistribute.
  6. Slice into half inch thick rounds and serve immediately. It should be pull apart tender and so delicious! Be sure to spoon a little of the juices from the pan over the meat as you serve it.

Close up of a slice of pork tenderloin.


The main difference is the cut – they come from totally different parts of the animal. Both are very lean cuts of meat, but giving their variance in size and shape, one cannot be substituted for the other.


The rule of thumb used to be that pork had to be eaten well done (165 degrees), which often resulted is a tough leathery piece of meat. The FDA now says that pork is safe to consume medium rare (145 degrees). This will give you a tender, juicy piece of pork that is slightly pink in the middle.

A close up o a sliced pork tenderloin with juices over it.


Trim it. There is a thin, silvery strip of skin that runs along one side of the pork. This is a tendon and you’ll want to be sure to trim that before cooking because it is quite tough to cut through if left attached.

Season it well. In this recipe we use cajun spices and brown sugar for a sweet and spicy pork tenderloin. You can also add flavor by adding fats, like butter or olive oil to a skillet and searing the meat before baking or roasting. Pork plays well with a variety of flavors, from sweet to savory to spicy.

Roast at a high temperature. I prefer to cook lean meats for less time and at higher temperatures. This method gives a nice color to the meat and also keeps it from drying out.

Don’t overcook it. Pork is a very lean meat and can become quite dry if overcooked, even a little bit. Since the FDA now approves pork to be cooked to a medium rare, I recommended erring on the rarer side.

Let it rest. Tent the tenderloin with foil right in the skillet and give it time to let the juices flow back through the meat, making for a tender and juicy bite every time. If cut too soon, the juices will spill out onto the cutting board and that’s just flavor escaping.

Slice into thick medallions. Using a sharp knife, slice pork tenderloin lengthwise into half inch rounds.


Our stand-bys that go with just about any meal are a crisp green salad and some of the Best Ever Cheesy Garlic Bread. But you can’t go wrong with any of these sides:

If you happen to have leftovers, they are great for Pork Fried Rice!

An overhead shot of Cajun Pork Tenderloin in a cast iron skillet.

More delicious pork recipes that you will love:

If you’ve made this recipe, please come back and leave us a star rating or a comment below. Or, tag us on social media @yellowblissroad or #yellowblissroad for a chance to be featured.
Pan with sliced Cajun pork tenderloin

Cajun Pork Tenderloin

This easy Cajun Pork Tenderloin is the perfect main attraction for any dinner and a simple 2-step process guarantees a tender, juicy bite every time.
Prep Time 5 mins
Cook Time 22 mins
Total Time 10 mins
Course Dinner
Cuisine American
Servings 6 servings
Calories 274kcal


  • 2 1/2 pounds pork tenderloin
  • 2 tablespoons cajun seasoning
  • 1 tablespoon brown sugar
  • 2 tablespoons butter or olive oil


  • Trim silvery skin from pork. Combine brown sugar and cajun seasoning, then rub the mixture into the meat.
  • Preheat oven to 425 degrees.
  • Heat butter or olive oil in a large, oven safe skillet. Sear tenderloin for two minutes per side to brown, then slide the skillet into the oven.
  • Roast for 18 minutes, then remove from the oven and tent with foil. Allow to rest for 5-10 minutes before slicing into ½ inch thick medallions.


Pork tenderloins can weigh anywhere from 1-2 pounds each. The recipe calls for 2 ½ pounds, which is typically two tenderloins. To ensure even cooking, be sure to use two tenderloins that are similar in size and weight.


Calories: 274kcalCarbohydrates: 3gProtein: 39gFat: 11gSaturated Fat: 5gCholesterol: 133mgSodium: 134mgPotassium: 796mgFiber: 1gSugar: 2gVitamin A: 1266IUCalcium: 17mgIron: 2mg
Keyword pork tenderloin

Cajun Pork Tenderloin in a cast iron skillet with text overlay.

Kristin Maxwell

Kristin Maxwell is the creator and main recipe developer, writer, and photographer of Yellow Bliss Road. A self-taught cook and self-appointed foodie, she specializes in easy, flavorful and approachable recipes for any home cook.

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  1. very interesting, I’ve learn a great Deal, i am a local pork roaster in jimeta Yola, Adamawa stated, Nigeria, I am always looking foreword to new method of how to wow my costumers in pork roasted, thanks for the clips.